Bojana Gligorijevic

Associate Professor & Director of Light Microscopy
 Bioengineering Department, Temple University
Co-Director, Biological Imaging Facility
Primary Member, Cancer Signaling & Epigenetics

 Fox Chase Cancer Center

1947 N 12th street
19122 Philadelphia, PA

Research Interests

Gligorijevic lab investigates mechanisms of tumor cell metastasis by implementing established and developing new microscopy technologies at multiple scales, combined with approaches from cell biology, tissue engineering and systems biology into a systems microscopy.
The focus of the lab is on analysis of tumor microenvironment complexity and emergent tumor cell behaviors as they relate to tumor microenvironment and its spatial and temporal changes, including extracellular matrix remodeling by tumor cells themselves. We strive towards predicting tumor cell decisions, which are a dynamical, ever-changing outcome of multiple mechanical and chemical signals from different cell-based and extracellular sources. While we are excited about engineering new technologies and highly curious about mechanistic understanding of metastasis, our overarching goal is to translate our findings into improved diagnostics for early metastasis and point to novel therapeutic targets.

Stefan Linder

Universitätsklinikum Eppendorf
Institut für Medizinische Mikrobiologe, Virologie und Hygiene
Campus Forschung, Gebäude N27
Martinistr. 52
20246 Hamburg

Research Interests

Our lab investigates podosomes in primary human cells. The aim of these studies is to elucidate the role of podosomes in physiological (immune cell migration, angiogenesis) and pathological contexts (atherosclerosis, endothelial dysfunction). We are particularly interested in the regulation of podosome dynamics (formation, fusion/fission, dissolution) in macrophages. Here, we focus on functional interactions between podosomes and microtubules, and on the delivery of regulatory factors through microtubule-based motor proteins to podosomes. Another focus in the lab is on podosome formation and function in endothelial cells, especially in regard to wound healing and endothelial integrity. Finally, we study the mechanisms of podosome-dependent matrix degradation through delivery and regulation of matrix-degrading enzymes.