Institut für Medizinische Mikrobiologe, Virologie und Hygiene
Campus Forschung, Gebäude N27
Our lab investigates podosomes in primary human cells. The aim of these studies is to elucidate the role of podosomes in physiological (immune cell migration, angiogenesis) and pathological contexts (atherosclerosis, endothelial dysfunction). We are particularly interested in the regulation of podosome dynamics (formation, fusion/fission, dissolution) in macrophages. Here, we focus on functional interactions between podosomes and microtubules, and on the delivery of regulatory factors through microtubule-based motor proteins to podosomes. Another focus in the lab is on podosome formation and function in endothelial cells, especially in regard to wound healing and endothelial integrity. Finally, we study the mechanisms of podosome-dependent matrix degradation through delivery and regulation of matrix-degrading enzymes.